Choosing between echo, pulse contour, transpulmonary thermodilution and pulmonary artery catheter, and what each number means.
At the bedside
- 1
Start with echo
ESICM 2014 recommends echocardiography as the first-line tool to assess type of shock. LVOT VTI x LVOT area x HR estimates CO; normal VTI 18-22 cm.
- 2
Choose advanced monitoring if not responding
Transpulmonary thermodilution (e.g. PiCCO, EV1000/VolumeView) or pulmonary artery catheter in severe shock, especially with ARDS or RV dysfunction.
- 3
Pulse contour analysis
Uncalibrated (FloTrac, LiDCO rapid, ProAQT) or calibrated (PiCCO). Good for trends and SVV; inaccurate with arrhythmia, aortic regurgitation, IABP, rapid vasopressor changes and damped traces.
- 4
Transpulmonary thermodilution
Cold saline (15-20 mL) via CVC, femoral arterial thermistor: CO, GEDVI (preload, normal 680-800 mL/m²), EVLWI (lung water, > 10 mL/kg = pulmonary oedema), PVPI (> 3 = permeability oedema).
- 5
Pulmonary artery catheter
CO (thermodilution), PAOP (wedge, LV filling), PAP, SvO2, PVR. Use in complex RV failure, pulmonary hypertension, cardiogenic shock and cardiac surgery; no routine benefit in general ICU patients.
- 6
Integrate, don't chase numbers
Use CO with MAP, perfusion markers (lactate, CRT, ScvO2, CO2 gap) and organ function to choose fluid vs vasopressor vs inotrope.
Cardiac output tools compared
| Tool | Invasiveness | Key outputs | Limitations |
|---|---|---|---|
| Echocardiography | None | LV/RV function, VTI, CO, pericardium, valves | Operator dependent, intermittent |
| Uncalibrated pulse contour | Arterial line | CO trend, SVV | Arrhythmia, AR, vasoplegia, damping |
| Transpulmonary thermodilution | CVC + femoral arterial line | CO, GEDVI, EVLWI, PVPI, SVV | Recalibrate every 8 h / after changes; cost |
| Pulmonary artery catheter | PA catheter | CO, PAOP, PAP, SvO2, PVR | Complications (arrhythmia, PA rupture), interpretation errors |
| Bioreactance / oesophageal Doppler | Non-/minimally invasive | CO trend | Validation varies |
Calculators for this topic
Pathophysiology
All monitors estimate flow indirectly. Thermodilution uses the Stewart-Hamilton principle (area under the temperature curve inversely proportional to flow). Pulse contour assumes a relationship between pressure waveform area and stroke volume that depends on vascular compliance, which changes in shock and with vasopressors, hence the need for calibration.
Evidence
- ESICM 2014 consensus: echocardiography first; advanced haemodynamic monitoring in patients not responding to initial therapy; PAC in refractory shock with RV dysfunction or ARDS [Cecconi 2014].
- RCTs of routine PAC use (e.g. PAC-Man, FACTT) showed no mortality benefit in general ICU populations.
Controversies
- Whether CO-guided protocols improve outcome; the evidence is mostly physiological and perioperative.
🇮🇳 India notes
- Thermodilution and pulse-contour kits are costly (several thousand rupees per patient) and are used selectively in Indian ICUs; trained echo is the realistic universal tool.
- Consider cost-benefit and insurance coverage before inserting advanced monitoring.
References
Test yourself
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Educational reference for trained clinicians. Check doses against your hospital protocol and the patient in front of you.

