Endotracheal tube size and depth, laryngoscope blades and supraglottic airways by age/weight, a safe paediatric rapid sequence intubation, and lung-protective initial ventilation per PALICC-2.
At the bedside
Timed steps- 1
Decide and call for help
BeforeIndications: failure to maintain/protect airway, refractory hypoxaemia or hypercapnia on HFNC/NIV, exhaustion, GCS ≤8, shock needing controlled ventilation, safe transfer. Call the most experienced airway operator available; children decompensate fast.
- 2
Calculate sizes aloud
BeforeCuffed ETT ID = (age/4) + 3.5; uncuffed = (age/4) + 4. Keep one size above and below. Oral depth (cm at lips) = 3 × ID or (age/2) + 12. Write the weight, tube size, depth and drug doses on a whiteboard.
- 3
Prepare
BeforeSuction (Yankauer + catheter 2 × ETT ID in Fr), bag-valve-mask of correct size, appropriate blade, stylet, bougie, SGA one size ready, waveform capnography, oral airway, NG tube. Fluid bolus 10–20 mL/kg drawn up and adrenaline (push-dose or infusion) ready if shocked.
- 4
Preoxygenate
−3 minHead position (shoulder roll in infants, sniffing in older child); 100% O₂ by mask for 3 min, or HFNC/NIV if already on it; continue apnoeic oxygenation via nasal cannula during laryngoscopy.
- 5
Induce and paralyse
0Ketamine 1–2 mg/kg (0.5–1 mg/kg in profound shock) ± fentanyl 1–2 mcg/kg; rocuronium 1–1.2 mg/kg. Atropine 0.02 mg/kg is not routine; consider for bradycardia or in infants receiving suxamethonium.
- 6
Intubate and confirm
+45–60 sVideo laryngoscope if available. Gentle bag-mask ventilation (low pressure) is acceptable if desaturating. Confirm with sustained waveform ETCO₂, chest rise and auscultation; cuff pressure <20–25 cmH₂O; chest X-ray for tip position (mid-trachea, T2–T3).
- 7
Plan B/C
FailedIf two attempts fail: oxygenate with bag-mask + adjuncts or an SGA, call for help. Cannot intubate, cannot oxygenate: in children <8 years needle cricothyroidotomy (cannula) with jet/bag oxygenation as a bridge; surgical airway in older children. Keep the drawn-up dose list for re-attempts.
- 8
Initial ventilation (PALICC-2)
AfterTidal volume 5–8 mL/kg predicted (ideal) weight; 3–6 mL/kg if poor compliance. Plateau ≤28 cmH₂O; driving pressure ≤15 cmH₂O; PEEP 5–8 then titrate to oxygenation and haemodynamics. SpO₂ 92–97% (88–92% acceptable in severe PARDS with PEEP ≥10). Permissive hypercapnia with pH ≥7.20, except in raised ICP or pulmonary hypertension.
Induction (haemodynamically safest)
Ketamine — paediatric
- Dose
- 1–2 mg/kg; 0.5–1 mg/kg in profound shock; IM 4–5 mg/kg if no access
- Worked example
- 20 kg: 20–40 mg IV (shocked: 10–20 mg).
Neuromuscular blockade for RSI
Rocuronium — paediatric
- Dose
- 1–1.2 mg/kg
- Worked example
- 20 kg: 20–24 mg (2–2.4 mL of 10 mg/mL).
Analgesic co-induction / post-intubation
Fentanyl — paediatric
- Dose
- 1–2 mcg/kg slowly; infusion 1–4 mcg/kg/h
- Range
- 1–4 mcg/kg/h
- Preparation
- 10 mcg/kg in 50 mL: 1 mL/h = 0.2 mcg/kg/h (or 50 mcg/mL undiluted for older children)
- Worked example
- 20 kg: bolus 20–40 mcg; infusion 2 mcg/kg/h = 40 mcg/h = 0.8 mL/h of 50 mcg/mL.
Bradycardia during intubation (not routine premedication)
Atropine — paediatric
- Dose
- 0.02 mg/kg (max single dose 0.5 mg)
- Worked example
- 20 kg: 0.4 mg.
Airway equipment by age
| Age (approx. weight) | Cuffed ETT ID (mm) | Oral depth at lips (cm) | Laryngoscope blade | SGA (LMA) size |
|---|---|---|---|---|
| Term newborn–<8 months (3–8 kg) | 3.0 | 9–10 | Miller 0–1 | 1 (<5 kg) / 1.5 (5–10 kg) |
| 8 months–2 years (8–12 kg) | 3.5 | 10.5–12 | Miller 1 / Mac 1 | 1.5 (5–10 kg) / 2 (10–20 kg) |
| 2 years (12 kg) | 4.0 | 12–13 | Mac 2 / Miller 2 | 2 |
| 4 years (16 kg) | 4.5 | 14 | Mac 2 | 2 |
| 6 years (20 kg) | 5.0 | 15 | Mac 2 | 2–2.5 (20–30 kg) |
| 8 years (25–30 kg) | 5.5 | 16 | Mac 2–3 | 2.5 |
| 10 years (30–35 kg) | 6.0 | 17–18 | Mac 3 | 3 (30–50 kg) |
| 12–14 years (40–50 kg) | 6.5–7.0 | 18–21 | Mac 3 | 3–4 (50–70 kg) |
Cuffed ID = age/4 + 3.5 (≥2 years); uncuffed = age/4 + 4. Depth ≈ 3 × ID. Always confirm with ETCO₂ and chest X-ray; have half-size smaller tubes for croup or subglottic narrowing.
PARDS severity on invasive ventilation (PALICC-2)
| Severity | Oxygenation index (OI) | Oxygen saturation index (OSI) |
|---|---|---|
| Mild/moderate | 4 to <16 | 5 to <12.3 |
| Severe | ≥16 | ≥12.3 |
OI = (FiO₂ × mean airway pressure × 100) / PaO₂; OSI uses SpO₂ (≤97%) in place of PaO₂.
Calculators for this topic
Oxygenation index
OI = FiO₂(%) × mean airway pressure ÷ PaO₂.
SpO₂/FiO₂ ratio
Non-invasive oxygenation ratio; valid only when SpO₂ ≤ 97%. Global ARDS definition uses S/F ≤ 315.
Infusion rate from per-kg-per-hour dose
Pump rate for drugs dosed per kg per hour (insulin U/kg/h, midazolam mg/kg/h, propofol mg/kg/h, fentanyl mcg/kg/h, dexmedetomidine mcg/kg/h).
References
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Paediatric intubation pathway
Step 1 of ~7
Preparation, RSI and rescue pathway for a sick child.
Call help; calculate tube, depth, drugs; prepare suction, SGA, ETCO₂
Based on Topjian AA, Raymond TT, Atkins D, et al; Lasa JJ, Dhillon GS, Duff JP, et al; Emeriaud G, López-Fernández YM, Iyer NP, et al. Educational use; follow local protocol.
Pathophysiology
Infants have a high oxygen consumption (6–8 mL/kg/min vs 3–4 mL/kg/min in adults) and small FRC, so safe apnoea time is very short. Poiseuille's law means 1 mm of oedema in an infant's 4 mm subglottis increases resistance about 16-fold — explaining why croup and post-extubation stridor are dangerous.
Evidence
- Cuffed vs uncuffed tubes: Weiss et al. 2009 (2,246 children <5 years, multicentre RCT) found cuffed tubes reduced tube exchanges (2.1% vs 30.8%) without increasing post-extubation stridor (4.4% vs 4.7%). AHA 2020/2025 supports cuffed tubes for infants and children.
- Cricoid pressure is not recommended routinely during paediatric intubation (AHA 2020/2025).
- Atropine premedication is not recommended routinely; reserve for bradycardia risk.
- PALICC-2 (2023): PARDS defined by OI/OSI on invasive ventilation (or P/F, S/F on non-invasive support); recommendations for tidal volume by compliance, plateau ≤28 cmH₂O, driving pressure ≤15 cmH₂O, SpO₂ targets, conservative fluids after resuscitation, and prone positioning considered in severe PARDS.
Controversies
- Video vs direct laryngoscopy as first-line in children (first-pass success better for novices with VL).
- Ketamine vs etomidate in shock (etomidate rarely stocked in Indian paediatric units; adrenal suppression concerns in sepsis).
- High-frequency oscillatory ventilation in severe PARDS — no recommendation as routine.
🇮🇳 India notes
- Cuffed paediatric tubes, size-appropriate video laryngoscope blades and paediatric ETCO₂ adapters may not be available in district hospitals — this is a reason to refer early to a PICU centre.
- Keep a paediatric airway trolley with a laminated size chart; many emergencies in Indian general ICUs involve teenagers (OP poisoning, snakebite, trauma) who can be managed with adult-sized equipment by weight.
- Suxamethonium remains widely used in India; avoid in hyperkalaemia, neuromuscular disease and burns >48 h, and give atropine in infants.
References
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