Look for adverse features and reversible causes (drugs, K+, ischaemia, hypothermia, hypothyroidism, raised ICP). Atropine first; if it fails or the block is infranodal, adrenaline or isoprenaline infusion and transcutaneous then transvenous pacing.
At the bedside
Timed steps- 1
Assess
0 minShock, syncope, ischaemia, heart failure, pauses > 3 s, Mobitz II, complete heart block with wide QRS, ventricular standstill.
- 2
Atropine
0-5 min0.5-1 mg IV every 3-5 min to 3 mg (ineffective after heart transplant and in infranodal block).
- 3
Chronotropes
5-15 minAdrenaline 2-10 mcg/min or isoprenaline 1-10 mcg/min (dopamine 5-20 mcg/kg/min alternative).
- 4
Transcutaneous
PacingRate 60-70, increase output until capture; confirm with femoral pulse; analgesia/sedation. Bridge to transvenous.
- 5
Transvenous
PacingRight internal jugular or left subclavian with ultrasound; ventricular capture threshold < 1 mA, output 3 × threshold.
- 6
Treat
Reversible causesBeta-blocker (glucagon), calcium-channel blocker (calcium, high-dose insulin), digoxin (Fab fragments), hyperkalaemia (calcium), inferior MI (often resolves after reperfusion), hypothermia, hypothyroidism, raised ICP, Lyme or infiltrative disease.
First-line
Atropine
- Dose
- 0.5-1 mg every 3-5 min (max 3 mg)
- Preparation
- 0.6 mg/mL: 1 mg ≈ 1.7 mL
Bridge to pacing
Isoprenaline (isoproterenol)
- Dose
- 1-10 mcg/min
Bradycardia
Step 1 of ~3
Decision: Adverse features or high-risk block?
Based on Glikson M, Nielsen JC, Kronborg MB, et al; Part 9: Adult Advanced Life Support: 2025 American Heart Association Guidelines for CPR and ECC. Educational use; follow local protocol.
Evidence
- ESC pacing 2021: acute management of bradycardia with atropine, isoprenaline/adrenaline, and temporary pacing only when needed (transvenous pacing has complications).
- AHA 2025: atropine 1 mg; adrenaline infusion or pacing if refractory.
🇮🇳 India notes
- Temporary pacing leads and pacing boxes may be held only by cardiology; know where they are at night.
References
Test yourself
Module quiz · score 70% to complete the module
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Educational reference for trained clinicians. Check doses against your hospital protocol and the patient in front of you.

