Module 37 · Skills & practice

Procedures

NewPhase 2

Bedside ICU procedures: ultrasound-guided central venous and arterial cannulation, thoracentesis and chest drains, lumbar puncture, paracentesis and pericardiocentesis, with coagulation thresholds, local anaesthetic safety and Indian context.

6 topics

Drugs in this module

Doses written for this module's context. The same drug may read differently in another module.

Lidocaine (lignocaine)

Amide local anaesthetic

Indications
Local infiltration for bedside procedures
Adult dose
Infiltration with 1% (10 mg/mL) or 2% solution. Maximum: 4.5 mg/kg plain (about 300 mg), 7 mg/kg with adrenaline (about 500 mg).
Preparation (India)
1% and 2% vials (plain or with adrenaline 1:200,000).
Cautions
Local anaesthetic systemic toxicity (perioral tingling, tinnitus, seizures, arrhythmia, arrest); aspirate before injecting; avoid adrenaline-containing solutions at end-arterial sites.
Monitoring
Neurological symptoms and ECG during and after large-volume infiltration.

Lipid emulsion 20%

Antidote for local anaesthetic systemic toxicity

Indications
LAST with seizures, arrhythmia or cardiovascular collapse
Adult dose
> 70 kg: 100 mL bolus over 2-3 min, then 200-250 mL over 15-20 min. ≤ 70 kg: 1.5 mL/kg bolus over 2-3 min, then 0.25 mL/kg/min. Repeat bolus once or twice and double infusion rate if unstable; maximum about 12 mL/kg.
Preparation (India)
20% lipid emulsion bags (parenteral nutrition products, e.g. 100 mL and 250 mL).
Cautions
Pancreatitis and lipaemic interference with labs; use with standard ACLS (reduced adrenaline doses ≤ 1 mcg/kg).

Intrapleural alteplase + dornase alfa

Fibrinolytic + mucolytic (intrapleural)

Indications
Pleural infection with poor drainage despite a chest drain
Adult dose
Alteplase 10 mg + dornase alfa 5 mg intrapleurally twice daily for 3 days (6 doses), each clamped for 1 h.
Cautions
Pleural bleeding; check coagulation and platelets; avoid with bronchopleural fistula.

Human albumin 20%

Colloid

Indications
Large-volume paracentesis (> 5 L)
Adult dose
6-8 g albumin per litre of ascites removed (e.g. 8 L removed: 48-64 g).
Preparation (India)
20% (20 g in 100 mL) and 5% vials; costly in India.
Cautions
Volume overload in cardiac disease.

Module references (16)

  1. 1

    Biggins SW, Angeli P, Garcia-Tsao G, et al. Diagnosis, evaluation, and management of ascites, spontaneous bacterial peritonitis and hepatorenal syndrome: 2021 practice guidance by the AASLD. Hepatology 2021;74:1014-48.

  2. 2

    American Society of Anesthesiologists Task Force on Central Venous Access. Practice Guidelines for Central Venous Access 2020. Anesthesiology 2020;132:8-43.

  3. 3

    Roberts ME, Rahman NM, Maskell NA, et al. British Thoracic Society Guideline for pleural disease. Thorax 2023;78(Suppl 3):s1-42.

  4. 4

    Farkas J. The Internet Book of Critical Care (IBCC). EMCrit Project; continuously updated.

  5. 5

    Lamperti M, Bodenham AR, Pittiruti M, et al. International evidence-based recommendations on ultrasound-guided vascular access. Intensive Care Med 2012;38:1105-17.

  6. 6

    Buetti N, Marschall J, Drees M, et al. Strategies to prevent central line-associated bloodstream infections in acute-care hospitals: 2022 update. Infect Control Hosp Epidemiol 2022;43:553-69.

  7. 7

    Lamperti M, Biasucci DG, Disma N, et al. European Society of Anaesthesiology guidelines on peri-operative use of ultrasound-guided for vascular access (PERSEUS vascular access). Eur J Anaesthesiol 2020;37:344-76.

  8. 8

    Patel IJ, Rahim S, Davidson JC, et al. Society of Interventional Radiology consensus guidelines for the periprocedural management of thrombotic and bleeding risk in patients undergoing percutaneous image-guided interventions - part II: recommendations. J Vasc Interv Radiol 2019;30:1168-84.

  9. 9

    van Baarle FLF, van de Weerdt EK, van der Velden WJFM, et al. Platelet transfusion before CVC placement in patients with thrombocytopenia (PACER). N Engl J Med 2023;388:1956-65.

  10. 10

    Horlocker TT, Vandermeuelen E, Kopp SL, et al. Regional anesthesia in the patient receiving antithrombotic or thrombolytic therapy: American Society of Regional Anesthesia and Pain Medicine evidence-based guidelines (fourth edition). Reg Anesth Pain Med 2018;43:263-309.

  11. 11

    Neal JM, Barrington MJ, Fettiplace MR, et al. The third American Society of Regional Anesthesia and Pain Medicine practice advisory on local anesthetic systemic toxicity: executive summary 2017. Reg Anesth Pain Med 2018;43:113-23.

  12. 12

    van de Beek D, Cabellos C, Dzupova O, et al. ESCMID guideline: diagnosis and treatment of acute bacterial meningitis. Clin Microbiol Infect 2016;22(Suppl 3):S37-62.

  13. 13

    Nath S, Koziarz A, Badhiwala JH, et al. Atraumatic versus conventional lumbar puncture needles: a systematic review and meta-analysis. Lancet 2018;391:1197-204.

  14. 14

    Rahman NM, Maskell NA, West A, et al. Intrapleural use of tissue plasminogen activator and DNase in pleural infection (MIST2). N Engl J Med 2011;365:518-26.

  15. 15

    Adler Y, Charron P, Imazio M, et al. 2015 ESC guidelines for the diagnosis and management of pericardial diseases. Eur Heart J 2015;36:2921-64.

  16. 16

    Schulz-Menger J, Collini V, Gröschel J, et al. 2025 ESC guidelines for the management of myocarditis and pericarditis. Eur Heart J 2025.