Module 8 · Airway & respiratory

Mechanical ventilation

NewPhase 1

Set safe initial ventilation for any intubated adult, understand volume, pressure and spontaneous modes, troubleshoot alarms and sudden deterioration with DOPES, read basic waveforms to detect asynchrony and auto-PEEP, liberate patients with daily SAT-SBT, and time tracheostomy sensibly.

6 topics

Drugs in this module

Doses written for this module's context. The same drug may read differently in another module.

Propofol

GABA-A agonist sedative

Indications
Light sedation for ventilated patients; allows daily sedation interruption.
Adult dose
0.5-4 mg/kg/h (≈ 5-50 mcg/kg/min). Avoid > 4 mg/kg/h for > 48 h.
Preparation (India)
1% (10 mg/mL) 20 mL and 50 mL vials; run undiluted in a 50 mL syringe.
Cautions
Hypotension; hypertriglyceridaemia (check TG every 48-72 h); propofol infusion syndrome (acidosis, rhabdomyolysis, arrhythmia) with high doses.

Fentanyl

Opioid analgesic

Indications
Analgesia-first sedation in ventilated patients.
Adult dose
Infusion 0.5-2 mcg/kg/h; bolus 25-50 mcg as needed.
Preparation (India)
50 mcg/mL; 1000 mcg in 50 mL = 20 mcg/mL (or 500 mcg in 50 mL = 10 mcg/mL).
Cautions
Accumulates with prolonged infusion; ileus; chest wall rigidity with rapid boluses.

Module references (10)

  1. 1

    Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med. 2000;342(18):1301-1308

  2. 2

    Writing Group for the PReVENT Investigators. Effect of a low vs intermediate tidal volume strategy on ventilator-free days in intensive care unit patients without ARDS. JAMA. 2018;320(18):1872-1880

  3. 3

    Girard TD, Alhazzani W, Kress JP, et al. An official ATS/ACCP clinical practice guideline: liberation from mechanical ventilation in critically ill adults. Am J Respir Crit Care Med. 2017;195(1):120-133

  4. 4

    Boles JM, Bion J, Connors A, et al. Weaning from mechanical ventilation. Eur Respir J. 2007;29(5):1033-1056

  5. 5

    Subirà C, Hernández G, Vázquez A, et al. Effect of pressure support vs T-piece ventilation strategies during spontaneous breathing trials on successful extubation. JAMA. 2019;321(22):2175-2182

  6. 6

    Girard TD, Kress JP, Fuchs BD, et al. Efficacy and safety of a paired sedation and ventilator weaning protocol (ABC trial). Lancet. 2008;371(9607):126-134

  7. 7

    Ely EW, Baker AM, Dunagan DP, et al. Effect on the duration of mechanical ventilation of identifying patients capable of breathing spontaneously. N Engl J Med. 1996;335(25):1864-1869

  8. 8

    Thille AW, Rodriguez P, Cabello B, Lellouche F, Brochard L. Patient-ventilator asynchrony during assisted mechanical ventilation. Intensive Care Med. 2006;32(10):1515-1522

  9. 9

    Young D, Harrison DA, Cuthbertson BH, Rowan K. Effect of early vs late tracheostomy placement on survival in patients receiving mechanical ventilation (TracMan). JAMA. 2013;309(20):2121-2129

  10. 10

    Thille AW, Muller G, Gacouin A, et al. Effect of postextubation high-flow nasal oxygen with noninvasive ventilation vs high-flow nasal oxygen alone on reintubation among patients at high risk of extubation failure (HIGH-WEAN). JAMA. 2019;322(15):1465-1475