A systematic 12-lead read, STEMI criteria and their mimics, troponin in critical illness, QTc risk and electrolyte patterns.
At the bedside
- 1
Rate and rhythm
Regular or irregular; P before every QRS; narrow vs broad complex (see cardiac-emergencies-arrhythmias module for management).
- 2
Intervals
PR 120-200 ms; QRS < 120 ms; QTc (Bazett, or Fridericia when HR > 100): > 500 ms or rise > 60 ms from baseline = high torsades risk.
- 3
ST elevation (STEMI)
New ST elevation at the J point in ≥ 2 contiguous leads: ≥ 1 mm in all leads except V2-V3, where ≥ 2 mm (men ≥ 40 y), ≥ 2.5 mm (men < 40 y), ≥ 1.5 mm (women).
- 4
STEMI equivalents
Posterior MI (ST depression V1-V3, tall R; check V7-V9), new LBBB with ischaemic symptoms or Sgarbossa criteria, de Winter T waves, diffuse ST depression with aVR elevation (left main / multivessel ischaemia).
- 5
Mimics
Pericarditis (diffuse concave ST elevation, PR depression), LV aneurysm, early repolarisation, hyperkalaemia, Brugada, Takotsubo, raised ICP (deep T inversion).
- 6
Troponin
Above the 99th percentile with a rise/fall = myocardial injury; MI requires ischaemic symptoms, ECG changes, imaging or angiographic evidence. Sepsis, PE, tachyarrhythmia, AKI and shock cause type 2 MI or non-ischaemic injury.
- 7
Electrolytes
Hyperkalaemia: peaked T → PR prolongation, P loss → broad QRS → sine wave. Hypokalaemia: U waves, ST depression. Hypocalcaemia: long QT. Hypercalcaemia: short QT.
Common ICU drugs that prolong QT
| Class | Examples |
|---|---|
| Antiarrhythmics | Amiodarone, sotalol, procainamide |
| Antipsychotics | Haloperidol (IV), quetiapine, olanzapine |
| Antimicrobials | Macrolides, fluoroquinolones, azoles, chloroquine/hydroxychloroquine |
| Antiemetics/GI | Ondansetron, domperidone, metoclopramide |
| Others | Methadone, tricyclics, citalopram |
Stop QT-prolonging drugs and correct K (to 4-5 mmol/L) and Mg when QTc > 500 ms.
Calculators for this topic
Troponin rise in an ICU patient
Step 1 of ~3
Decision: Rise/fall on repeat testing?
Based on Thygesen K, Alpert JS, Jaffe AS, et al; Byrne RA, Rossello X, Coughlan JJ, et al. Educational use; follow local protocol.
Pathophysiology
Critical illness raises myocardial oxygen demand (tachycardia, catecholamines) and reduces supply (hypotension, anaemia, hypoxaemia), causing type 2 MI; direct injury comes from sepsis, myocarditis, PE (RV strain) and toxins.
Evidence
- Fourth universal definition of MI [Thygesen 2018].
- ESC 2023 ACS guideline: STEMI criteria and equivalents [Byrne 2023].
- AHA/ACCF 2010 statement on torsades prevention in hospital [Drew 2010].
Controversies
- Benefit of coronary angiography for type 2 MI; QT correction formula at high heart rates.
🇮🇳 India notes
- Indian patients present with ACS at younger ages; STEMI equivalents in ICU are under-recognised.
- High-sensitivity troponin assays and cut-offs differ by laboratory - always use the local 99th percentile.
References
Test yourself
Module quiz · score 70% to complete the module
Educational reference for trained clinicians. Check doses against your hospital protocol and the patient in front of you.

